Zepbound® (tirzepatide) is a once-weekly injectable prescription medication used to support chronic weight management in adults, when combined with reduced-calorie nutrition and increased physical activity. It works by activating dual GIP and GLP-1 receptors that regulate appetite, satiety, and metabolic signaling.

Zepbound® is available through Skinii following a licensed telehealth consultation and medical evaluation.

How It Works

Tirzepatide targets two hormone pathways involved in hunger and blood sugar regulation:

• GLP-1 receptor activation helps reduce appetite and slow gastric emptying.

• GIP receptor activation supports metabolic efficiency and insulin response.

Together, these mechanisms promote reduced calorie intake and improved appetite control when used as part of a structured wellness program.

Administration

• Route: Subcutaneous injection

• Frequency: Once weekly, on the same day each week

• Injection sites: Abdomen, thigh, or upper arm (rotate sites as directed)

• Dose: Determined and adjusted by your prescribing provider

Always follow your provider’s instructions for dosing, titration, and administration.

Available Doses

Zepbound® is built to scale with your progress:

• 2.5mg (Starter)
• 5mg
• 7.5mg
• 10mg
• 12.5mg
• 15mg (Max)

Your provider will gradually titrate you up over time to optimize effectiveness and tolerance.

Who May Be Eligible

Zepbound® may be prescribed for adults who meet medical criteria for weight management as determined by a licensed healthcare provider during a telehealth evaluation.

Eligibility is based on individual health history, current medications, and clinical appropriateness.

Storage

• Refrigerate between 36°F–46°F (2°C–8°C)

• Do not freeze

• Protect from light

• Keep out of reach of children

Follow all storage instructions included with your medication.

Important Safety Information

Zepbound® is a prescription medication and may cause side effects. Common side effects may include:

• Nausea

• Vomiting

• Diarrhea or constipation

• Decreased appetite

• Abdominal discomfort

• Injection site reactions

Serious risks may include pancreatitis, gallbladder disease, kidney injury, and possible thyroid tumors.

Zepbound® should not be used in individuals with:

• A personal or family history of medullary thyroid carcinoma (MTC)

• Multiple endocrine neoplasia syndrome type 2 (MEN 2)

• Known hypersensitivity to tirzepatide

Tell your provider about all medical conditions and medications before starting therapy.

Seek medical attention for severe abdominal pain, persistent vomiting, difficulty swallowing, neck swelling, or allergic reactions.

Prescription Disclaimer
Zepbound® is available only with a valid prescription after evaluation by a licensed healthcare provider. Individual results vary. This medication is intended for prescribed therapeutic use only. These statements have not been evaluated by the Food and Drug Administration.

FAQ – Zepbound® Injectable

Q: What is Zepbound®?
A: Zepbound® is a prescription injectable medication containing tirzepatide. It is used for chronic weight management in adults when combined with reduced-calorie nutrition and increased physical activity.

Q: How does Zepbound® work?
A: Zepbound® activates two hormone receptors involved in appetite regulation and metabolic signaling. This helps reduce hunger, increase feelings of fullness, and support healthier eating patterns over time.

Q: How often is Zepbound® taken?
A: Zepbound® is administered once weekly by subcutaneous injection on the same day each week, or as directed by your prescribing provider.

Q: Where do I inject Zepbound®?
A: Injections are typically given in the abdomen, thigh, or upper arm. Injection sites should be rotated to reduce irritation.

Q: How long does it take to see results?
A: Many patients begin noticing appetite changes within the first few weeks. Weight changes vary based on individual metabolism, dosage, nutrition, and activity level. Consistent use as prescribed is important for best results.

Q: Do I need a prescription for Zepbound®?
A: Yes. Zepbound® is a prescription-only medication. A licensed Skinii provider must evaluate you through a telehealth consultation before prescribing.

Q: What are the most common side effects?
A: Common side effects may include nausea, vomiting, diarrhea, constipation, decreased appetite, abdominal discomfort, and injection site reactions. These often improve as the body adjusts.

Q: Are there serious risks with Zepbound®?
A: Serious risks may include pancreatitis, gallbladder disease, kidney injury, and possible thyroid tumors. Contact your provider immediately if you experience severe abdominal pain, persistent vomiting, neck swelling, or allergic reactions.

Q: Who should not use Zepbound®?
A: Zepbound® should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC), multiple endocrine neoplasia syndrome type 2 (MEN 2), or known hypersensitivity to tirzepatide.

Q: Can I take Zepbound® with other medications?
A: Always inform your provider of all medications, supplements, and medical conditions before starting Zepbound®. Your provider will determine safety and compatibility.

Q: Do I need to follow a specific diet while taking Zepbound®?
A: Zepbound® is intended to be used alongside a reduced-calorie nutrition plan and healthy lifestyle habits as guided by your provider.

Q: What happens if I miss a dose?
A: If you miss a dose, follow your provider’s instructions. Do not double doses unless specifically directed by your healthcare provider.